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This laboratory, led by Dr. Roland Kaunas, is focused on determining the stresses and strains generated in vascular cells in response to hemodynamic stimuli such as tensile stretch and fluid shear stress, and how these mechanical signals are transduced into intracellular signals leading to changes in cell behavior. Past and current projects include studies on the role of cytoskeletal organization on mechanotransduction, estimation of the mechanical properties of endothelial and smooth muscle cells, and the effects of flow on angiogenesis.
