Surface-Induced Thrombosis on Blood-Contacting Devices

Surface-induced thrombosis readily occurs on blood-contacting devices to compromise performance and even cause an embolism.

Thus, many blood-contacting devices rely on anticoagulants (heparin) and anti-platelet drugs which have complications associated with them.

Since the first step in surface-induced thrombosis is non-specific protein adhesion, protein-resistant surfaces may prevent clotting.

Grunlan Group Research:

The ability of PEO (or PEG) to prevent protein clotting in vivo has been disappointing. In our research, we are developing PEO-based coatings (crosslinked silicones and surface-grafted coatings) in which the PEO is connected to the surface by a flexible, hydrophobic siloxane tether. We have demonstrated that protein adhesion is reduced with this design. This behavior is attributed to the enhanced configurational mobility and amphiphilicity of the coatings.